Addressing Sample Contamination with Advanced Vial Cleaning Methods

6 Steps to Prepare Chromatography Vials for Analysis

May 30, 2023 · Thoroughly cleaning and washing vials is necessary to removing residues or contaminants that could interfere with analysis, so different cleaning methods and solvents should be chosen based on their nature as well as the material of the vial itself. This step helps preserve sample purity while also preventing cross-contamination.

TOC Issues: Part 1 - Sampling Materials

This Cleaning Memo will address the proper selection of sampling materials used if Total Organic Carbon (TOC) is the sampling method of choice. Particularly since TOC is subject to a multitude of interferences, it is necessary to make sure that the sampling materials provide a consistent TOC value due to those “interfering” materials.

Evaluation of surface contamination with cyclophosphamide

Prior to each trial and after cleaning with Surface Safe, a wipe sample was collected from the demarcated surface areas of the BSC workbench, BSC airfoil/grill, and the floor to determine if the surfaces were free from cyclophosphamide contamination. Vials were placed on protective/absorbent pads on either side of the demarcated area within the

Environmental contamination with cytotoxic drugs in 15

Interpretation of wipe sample results and choice of reference value. Wipe sample results were reported in ng/cm 2.A substance independent reference or guidance value of 0.1 ng/cm 2 was initially chosen on the basis of German references and available literature and was later confirmed by the study results as sufficiently close to the 90th percentile of the measured contamination within the

Hazardous drug residue on exterior vial surfaces: evaluation

Methods: This study includes separate evaluations for the presence or absence of surface drug contamination on the vials of 3 HD products: 5-fluorouracil, cisplatin, and methotrexate. The drug products were packaged in vials using a patented prewashing/decontamination method, application of a polyvinylchloride (PVC) base, and use of clear glass

SW-846 Chapter Four: Organic Analytes - Energy

procedures described in Method 5035 may minimize sample preparation analyte loss better than the procedures described in Methods 5031 and 5032. The vials and septa should be washed with soap and water and rinsed with distilled deionized water. After thoroughly cleaning the vials and septa, they should be placed in an oven and dried at 100

CHAPTER FOUR TABLE OF CONTENTS Section Page 4-1 RECOMMENDED

Dec 11, 2018 · contamination, a trip blank prepared from organic-free reagent water (as defined in Chapter One) should be maintained with the samples throughout sampling, shipping, and storage. Including activated carbon in the bags containing the sample vials may help reduce concerns related to these potential sources of sample contamination.

Best Practices for Using an Aijiren LC System Technical Note

How to clean the system • If bacterial contamination of the system is su spected the following syst em cleaning procedure can be used. • Apply the following solutions sequentially at a moderate flow rate (0.5 – 1 mL/min) for at least 30 min each: a Water b 0.1 M NaOH c Water d 0.13 M HCl e Water

Cyclophosphamide Contamination Observed on the External

Jul 28, 2008 · It suggests that cleaning vials from manufacturers and wholesalers may help to reduce the risk of occupational exposure. There is a need for a pilot study to establish guidelines on decontamination agents and cleaning process to eliminate the presence of contamination on vial surfaces. No conflicting interests are declared. References

Simplifying GC Syringes and Sample Introduction - Aijiren

Simplifying GC Syringes and Sample Introduction. A complex process dependent on many variables. General purpose, excellent choice for transferring liquids from ampoules or vials. For manual GC injections, a bevel tip is preferred for optimum septum penetration with minimal coring.

Hepatitis C Contamination of Medication Vials Accessed with

When a medication vial diaphragm is contaminated with hepatitis C virus, the contents of the vial can become contaminated with subsequent access with a clean syringe, and the viral content is sufficient to infect cells in culture. Hepatitis C virus remains infectious in contaminated medications for several days. Cleaning the vial surface with 70% isopropyl alcohol does not eliminate the risk

Cyclophosphamide contamination observed on the external

Nov 1, 2008 · This pilot study demonstrates the presence of contamination on the external surfaces of cyclophosphamide vials from two manufacturers on the Canadian market and suggests that cleaning vialsFrom manufacturers and wholesalers may help to reduce the risk of occupational exposure. OBJECTIVE Evaluate contamination on the external surfaces of cyclophosphamide vials available on the Canadian market

Mitigating Cross-Contamination in Shared Production

establishing a cleaning limit, stating that it must be practical and achievable by a reasonable cleaning procedure and must be verifiable by analytical methodology that exists in the company. 1 Harder’s

How can we avoid the unknown peaks in samples injection when

Agree with the previous 2 answers. It could be "ghost peaks" from material bound to the solid phase of the column from previous injections. Another possibility is a change in method, e.g. with